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KMID : 0191120000150020203
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Journal of Korean Medical Science
2000 Volume.15 No. 2 p.203 ~ p.210
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Effects of decreased cerebral perfusion pressure on cerebral hemodynamics, brain cell membrane function and energy metabolism during the early phase of experimental Escherichia coli meningitis in the newborn piglet
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Park WS
Chang YS
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Abstract
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In this study, we tested the hypothesis that decreased cerebral perfusion pressure (CPP)
induces cerebral ischemia and worsen brain damage in neonatal bacterial meningitis.
Meningitis was induced by intracisternal injection of 10(9) colony forming units of
Escherichia coli in 21 newborn piglets. Although CPP decreased significantly at 8 hr after
bacterial inoculation, deduced hemoglobin (HbD), measured as an index of changes in cerebral
blood flow by near infrared spectroscopy, did not decrease significantly. In correlation
analyses, CPP showed significant positive correlation with brain ATP and inverse correlation
with brain lactate levels. CPP also correlated positively with HbD and oxidized cytochrome
aa3 (Cyt aa3) by near infrared spectroscopy. However, CPP did not show significant correlation
with cerebral cortical cell membrane Na+,K+-ATPase activity, nor with levels of lipid peroxidation
products. In summary, decreased CPP observed in this study failed to induce cerebral ischemia and
further brain injury, indicating that cerebrovascular autoregulation is intact during the early
phase of experimental neonatal bacterial meningitis.
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KEYWORD
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